Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
tumor immune evasion
|
| gptkbp:community |
immune responses
|
| gptkbp:function |
immune checkpoint
|
| gptkbp:has_influence_on |
therapeutic outcomes
|
| gptkbp:has_role |
tumor microenvironment
autoimmunity cancer immunotherapy |
| https://www.w3.org/2000/01/rdf-schema#label |
PD-L2
|
| gptkbp:initiated_by |
T cell activation
immune checkpoint inhibitors |
| gptkbp:interacts_with |
gptkb:PD-1
|
| gptkbp:involved_in |
immune response
regulation of immune system |
| gptkbp:is_associated_with |
disease progression
regulatory T cells poor prognosis in cancer tumor microenvironment remodeling |
| gptkbp:is_expressed_in |
gptkb:myeloid-derived_suppressor_cells
gptkb:tumor_infiltrating_lymphocytes gptkb:Cell inflammation macrophages lymphoid tissues dendritic cells solid tumors cancer stem cells tumor cells hematopoietic cells neoplastic tissues tumor-associated macrophages cancer-associated fibroblasts lymphatic tissues peripheral blood mononuclear cells |
| gptkbp:is_found_in |
human tissues
|
| gptkbp:is_involved_in |
immune evasion mechanisms
adaptive immunity tumor progression immune response modulation immune checkpoint blockade tumor immune interactions immune cell regulation cancer metastasis immune surveillance cancer immunoediting cancer therapy resistance tumor escape mechanisms immune checkpoint therapy T cell exhaustion T cell tolerance cancer immunotherapy strategies immune checkpoint signaling tumor immune microenvironment |
| gptkbp:is_linked_to |
immune tolerance
chronic inflammation chronic infections |
| gptkbp:is_part_of |
immune checkpoint pathways
|
| gptkbp:is_regulated_by |
transcription factors
cytokines |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
clinical trials
monoclonal antibodies |
| gptkbp:knockouts |
PD-1 receptor
|
| gptkbp:located_in |
cell membrane
|
| gptkbp:promoter |
PDCD1 LG2
|
| gptkbp:related_to |
PD-1 pathway
|
| gptkbp:bfsParent |
gptkb:PD-1
|
| gptkbp:bfsLayer |
6
|