Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
tumor immune evasion
|
| gptkbp:combatants |
PD-1 receptor
|
| gptkbp:community |
immune responses
|
| gptkbp:established |
T cell activation
immune checkpoint inhibitors |
| gptkbp:function |
immune checkpoint
|
| gptkbp:has_influence_on |
therapeutic outcomes
|
| gptkbp:has_role |
tumor microenvironment
autoimmunity cancer immunotherapy |
| https://www.w3.org/2000/01/rdf-schema#label |
PD-L2
|
| gptkbp:interacts_with |
gptkb:PD-1
|
| gptkbp:is_aimed_at |
clinical trials
monoclonal antibodies |
| gptkbp:is_associated_with |
disease progression
regulatory T cells poor prognosis in cancer tumor microenvironment remodeling |
| gptkbp:is_found_in |
human tissues
|
| gptkbp:is_involved_in |
immune response
immune evasion mechanisms adaptive immunity tumor progression immune response modulation immune checkpoint blockade tumor immune interactions immune cell regulation cancer metastasis immune surveillance cancer immunoediting cancer therapy resistance tumor escape mechanisms immune checkpoint therapy T cell exhaustion T cell tolerance cancer immunotherapy strategies immune checkpoint signaling regulation of immune system tumor immune microenvironment |
| gptkbp:is_linked_to |
immune tolerance
chronic inflammation chronic infections |
| gptkbp:is_part_of |
immune checkpoint pathways
|
| gptkbp:is_represented_in |
gptkb:myeloid-derived_suppressor_cells
gptkb:tumor_infiltrating_lymphocytes gptkb:smartphone inflammation macrophages lymphoid tissues dendritic cells solid tumors cancer stem cells tumor cells hematopoietic cells neoplastic tissues tumor-associated macrophages cancer-associated fibroblasts lymphatic tissues peripheral blood mononuclear cells |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:located_in |
cell membrane
|
| gptkbp:promoter |
PDC D1 L G2
|
| gptkbp:regulates |
transcription factors
cytokines |
| gptkbp:related_to |
PD-1 pathway
|
| gptkbp:bfsParent |
gptkb:PD-1
|
| gptkbp:bfsLayer |
5
|