|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CD279
gptkb:PD-1
Programmed cell death 1
|
|
gptkbp:associatedWith
|
gptkb:immunotherapy
autoimmune diseases
|
|
gptkbp:discoveredBy
|
gptkb:Tasuku_Honjo
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodes
|
gptkb:Programmed_cell_death_protein_1
|
|
gptkbp:Entrez_Gene_ID
|
5133
ENSG00000188389
PDCD1
|
|
gptkbp:expressedIn
|
gptkb:B_cells
gptkb:T_cells
myeloid cells
|
|
gptkbp:function
|
regulation of immune response
|
|
gptkbp:GO_term
|
gptkb:GO:0006955_(immune_response)
GO:0001816 (cytokine production)
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:8765
|
|
gptkbp:interactsWith
|
gptkb:PD-L2
PD-L1
|
|
gptkbp:involvedIn
|
immune checkpoint pathway
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
2q37.3
|
|
gptkbp:mutationAssociatedWith
|
gptkb:systemic_lupus_erythematosus
multiple sclerosis
type 1 diabetes
rheumatoid arthritis
cancer susceptibility
|
|
gptkbp:OMIM
|
600244
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Pdcd1
|
|
gptkbp:product
|
gptkb:PD-1
|
|
gptkbp:proteinFamily
|
gptkb:immunoglobulin_superfamily
transmembrane domain
cytoplasmic tail
IgV-like domain
|
|
gptkbp:regulates
|
T cell activation
autoimmunity
immune exhaustion
peripheral tolerance
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:target
|
immune checkpoint inhibitors
|
|
gptkbp:targetOfDrug
|
gptkb:pembrolizumab
gptkb:cemiplimab
gptkb:nivolumab
|
|
gptkbp:UniProtID
|
Q15116
|
|
gptkbp:bfsParent
|
gptkb:programmed_cell_death_protein_1_(PD-1)
gptkb:CD279
gptkb:PD-1
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDCD1 gene
|