|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PTPN1
gptkb:PTP-1B
Tyrosine-protein phosphatase non-receptor type 1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:type_2_diabetes
obesity
|
|
gptkbp:clinicalTrialPhase
|
PTP1B inhibitors in metabolic disease
|
|
gptkbp:discoveredBy
|
Tonks and colleagues
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:encodedBy
|
PTPN1 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000196377
|
|
gptkbp:enzymeClassification
|
EC 3.1.3.48
|
|
gptkbp:fullName
|
gptkb:Protein_Tyrosine_Phosphatase,_Non-Receptor_Type_1
|
|
gptkbp:function
|
dephosphorylation of tyrosine residues
negative regulation of insulin signaling
regulation of leptin signaling
|
|
gptkbp:gene
|
gptkb:PTPN1
|
|
gptkbp:GO_term
|
gptkb:GO:0004725
|
|
gptkbp:highestExpression
|
gptkb:skeletal_muscle
liver
adipose tissue
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTP1B
|
|
gptkbp:inhibitedBy
|
small molecule inhibitors under investigation
|
|
gptkbp:interactsWith
|
gptkb:Src
gptkb:LEPR
gptkb:IRS1
|
|
gptkbp:locatedOnChromosome
|
chromosome 20q13.13
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:molecularWeight
|
50 kDa
|
|
gptkbp:mutationAssociatedWith
|
altered body weight regulation
altered insulin sensitivity
|
|
gptkbp:OMIM
|
176885
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ptpn1
|
|
gptkbp:PDB
|
gptkb:2HNP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
sumoylation
|
|
gptkbp:RefSeq
|
NP_002818
|
|
gptkbp:regulates
|
regulated by phosphorylation and oxidation
|
|
gptkbp:structure
|
contains a catalytic domain and a C-terminal hydrophobic region
|
|
gptkbp:substrate
|
gptkb:JAK2
gptkb:EGFR
gptkb:insulin_receptor
|
|
gptkbp:targetOfDrug
|
gptkb:cancer
gptkb:type_2_diabetes
obesity
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
gptkb:P18031
|
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gptkbp:bfsParent
|
gptkb:PTPN1
|
|
gptkbp:bfsLayer
|
7
|