|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PTPN1
gptkb:PTP1B
Tyrosine-protein phosphatase non-receptor type 1
|
|
gptkbp:associatedWith
|
gptkb:metabolic_syndrome
insulin resistance
|
|
gptkbp:discoveredBy
|
Nicholas K. Tonks
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:Entrez_Gene_ID
|
5770
|
|
gptkbp:enzymeCommissionNumber
|
EC 3.1.3.48
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
adipose tissue
|
|
gptkbp:fullName
|
Protein Tyrosine Phosphatase 1B
|
|
gptkbp:function
|
dephosphorylation of tyrosine residues
|
|
gptkbp:gene
|
gptkb:PTPN1
|
|
gptkbp:homologInRat
|
Ptpn1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTP-1B
|
|
gptkbp:inhibitedBy
|
gptkb:MSI-1436
gptkb:sodium_orthovanadate
gptkb:trodusquemine
BVT948
Cinnamic acid derivatives
Ertiprotafib
|
|
gptkbp:locatedOnChromosome
|
chromosome 20q13.1
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:molecularWeight
|
50 kDa
|
|
gptkbp:OMIM
|
176885
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ptpn1
|
|
gptkbp:PDB
|
gptkb:1PTY
gptkb:2HNP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
sumoylation
|
|
gptkbp:regulates
|
gptkb:leptin_signaling_pathway
cell differentiation
metabolism
cell growth
insulin signaling pathway
|
|
gptkbp:role
|
gptkb:cancer
gptkb:type_2_diabetes
obesity
|
|
gptkbp:structure
|
contains PTP domain
|
|
gptkbp:substrate
|
gptkb:insulin_receptor
leptin receptor
|
|
gptkbp:target
|
anti-obesity drugs
antidiabetic drugs
|
|
gptkbp:UniProtID
|
gptkb:P18031
|
|
gptkbp:bfsParent
|
gptkb:PTPN1
|
|
gptkbp:bfsLayer
|
7
|