Protein Tyrosine Phosphatase, Non-Receptor Type 1

URI: https://gptkb.org/entity/Protein_Tyrosine_Phosphatase,_Non-Receptor_Type_1
GPTKB entity
Statements (37)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:PTP1B
gptkbp:associatedWith gptkb:type_2_diabetes
obesity
gptkbp:biologicalProcess protein tyrosine phosphatase activity
gptkbp:Entrez_Gene_ID GC20M037282
gptkbp:enzymeCommissionNumber 3.1.3.48
gptkbp:expressedIn gptkb:skeletal_muscle
liver
adipose tissue
gptkbp:function dephosphorylation of tyrosine residues
gptkbp:gene gptkb:PTPN1
gptkbp:HGNC_ID 9644
https://www.w3.org/2000/01/rdf-schema#label Protein Tyrosine Phosphatase, Non-Receptor Type 1
gptkbp:inhibitedBy gptkb:insulin_receptor
gptkb:MSI-1436
gptkb:trodusquemine
leptin receptor
sodium vanadate
gptkbp:involves cell differentiation
cell growth
oncogenic transformation
mitotic cycle
gptkbp:length 435
gptkbp:locatedIn gptkb:cytoplasm
gptkbp:locatedOnChromosome gptkb:20q13.13
gptkbp:molecularWeight 49 kDa
gptkbp:OMIM 176885
gptkbp:PDB gptkb:2HNP
gptkbp:regulates insulin signaling
leptin signaling
gptkbp:target type 2 diabetes drugs
obesity drugs
gptkbp:UniProtID gptkb:P18031
gptkbp:bfsParent gptkb:PTPN1
gptkbp:bfsLayer 7