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gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:PTPN1
gptkb:PTP-1B
Tyrosine-protein phosphatase non-receptor type 1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:type_2_diabetes
obesity
|
|
gptkbp:discoveredBy
|
Tonks and colleagues
|
|
gptkbp:discoveredIn
|
1988
|
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gptkbp:EC_number
|
3.1.3.48
|
|
gptkbp:encodedBy
|
PTPN1 gene
|
|
gptkbp:fullName
|
gptkb:Protein_Tyrosine_Phosphatase,_Non-Receptor_Type_1
|
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gptkbp:function
|
dephosphorylation of tyrosine residues on proteins
|
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gptkbp:gene
|
gptkb:PTPN1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTP1B phosphatase
|
|
gptkbp:inhibitedBy
|
gptkb:insulin_receptor
leptin receptor
small molecule inhibitors under investigation
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gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
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gptkbp:locatedOnChromosome
|
gptkb:20q13.13
|
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gptkbp:molecularWeight
|
50 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:2HNP
|
|
gptkbp:regulates
|
gptkb:leptin_signaling_pathway
insulin signaling pathway
|
|
gptkbp:structure
|
contains a catalytic domain and a C-terminal hydrophobic region
|
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gptkbp:UniProtID
|
gptkb:P18031
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gptkbp:bfsParent
|
gptkb:PTPN1
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gptkbp:bfsLayer
|
7
|