POU domain, class 5, transcription factor 1

URI: https://gptkb.org/entity/POU_domain,_class_5,_transcription_factor_1
GPTKB entity
Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:Oct4
Oct-4
gptkbp:associatedWith stem cell pluripotency
gptkbp:discoveredBy gptkb:Hans_R._Schöler
gptkbp:discoveredIn 1989
gptkbp:domain homeobox domain
POU domain
gptkbp:encodedBy gptkb:POU5F1_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000204531
5460
gptkbp:expressed_during early embryogenesis
gptkbp:expressedIn gptkb:germ_cells
embryonic stem cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function transcription factor
regulation of pluripotency
maintenance of self-renewal in embryonic stem cells
gptkbp:gene gptkb:POU5F1
gptkbp:geneType protein-coding
gptkbp:GO_term GO:0003677 (DNA binding)
GO:0003700 (DNA-binding transcription factor activity)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
gptkbp:HGNC_ID 9221
https://www.w3.org/2000/01/rdf-schema#label POU domain, class 5, transcription factor 1
gptkbp:interactsWith gptkb:NANOG
gptkb:KLF4
gptkb:SOX2
gptkb:c-MYC
gptkbp:involves induced pluripotent stem cell generation
gptkbp:locatedOnChromosome gptkb:chromosome_6p21.31
gptkbp:location gptkb:nucleus
gptkbp:molecularWeight ~39 kDa
gptkbp:mutationAssociatedWith infertility
germ cell tumors
gptkbp:OMIM 164177
gptkbp:orthologInMouse Pou5f1
gptkbp:orthologInZebrafish pou5f3
gptkbp:PDB 3L1P
gptkbp:RefSeq NM_002701
gptkbp:regulates cell differentiation
gene expression
cell fate determination
developmental processes
gptkbp:requires maintenance of pluripotency
inner cell mass formation
gptkbp:structure contains POU-specific and POU-homeodomain separated by a linker
gptkbp:UniProtID gptkb:Q01860
gptkbp:used_as_marker_for pluripotent stem cells
gptkbp:used_in gptkb:Yamanaka_factors
gptkbp:bfsParent gptkb:Oct4
gptkb:POU5F1
gptkb:POU5F1_gene
gptkbp:bfsLayer 7