|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
fructose-1,6-bisphosphate
|
|
gptkbp:alternativeName
|
gptkb:M2-type_pyruvate_kinase
gptkb:PKM2_isoform
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:cofactor
|
K+
Mg2+
|
|
gptkbp:component
|
cytosol
|
|
gptkbp:encodedBy
|
gptkb:PKM_gene
|
|
gptkbp:Entrez_Gene_ID
|
5315
|
|
gptkbp:enzymeCommissionNumber
|
2.7.1.40
|
|
gptkbp:fullName
|
gptkb:Pyruvate_kinase_M2
|
|
gptkbp:function
|
catalyzes the final step of glycolysis
pyruvate kinase activity
|
|
gptkbp:GOProcess
|
glycolytic process
|
|
gptkbp:hasIsoform
|
gptkb:pyruvate_kinase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PKM2
|
|
gptkbp:inhibitedBy
|
phenylalanine
|
|
gptkbp:interactsWith
|
gptkb:HIF-1α
gptkb:β-catenin
gptkb:STAT3
phosphotyrosine proteins
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15q23
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~58 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:nonspherocytic_hemolytic_anemia
|
|
gptkbp:OMIM
|
609293
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:1T5A
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
acetylation
|
|
gptkbp:product
|
gptkb:pyruvate
|
|
gptkbp:RefSeq
|
gptkb:NP_002645.3
|
|
gptkbp:regulates
|
phosphorylation
oxidation
acetylation
allosteric
|
|
gptkbp:roleInCancer
|
gptkb:Warburg_effect
tumor metabolism
|
|
gptkbp:significance
|
therapeutic target
cancer biomarker
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
tetramer or dimer
|
|
gptkbp:substrate
|
phosphoenolpyruvate
|
|
gptkbp:tissue_specificity
|
tumor cells
embryonic tissues
proliferating cells
|
|
gptkbp:UniProtID
|
P14618
|
|
gptkbp:bfsParent
|
gptkb:pyruvate_kinase
|
|
gptkbp:bfsLayer
|
6
|