|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
serine
fructose-1,6-bisphosphate
|
|
gptkbp:alternativeName
|
Pyruvate kinase isozymes M2
Tumor M2-PK
|
|
gptkbp:alternativeSplicing
|
produced by alternative splicing of PKM gene
|
|
gptkbp:component
|
cytosol
|
|
gptkbp:encodedBy
|
gptkb:PKM_gene
|
|
gptkbp:Entrez_Gene_ID
|
5315
|
|
gptkbp:enzymeCommissionNumber
|
2.7.1.40
|
|
gptkbp:expressedIn
|
tumor cells
embryonic tissues
proliferating cells
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
Pyruvate kinase muscle isoform 2
|
|
gptkbp:function
|
catalyzes the final step of glycolysis
pyruvate kinase activity
|
|
gptkbp:GOProcess
|
glycolytic process
|
|
gptkbp:hasBiomarker
|
cancer diagnosis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PKM2 isoform
|
|
gptkbp:inhibitedBy
|
shikonin
TEPP-46
|
|
gptkbp:interactsWith
|
gptkb:HIF-1α
gptkb:β-catenin
gptkb:STAT3
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15q23
|
|
gptkbp:molecularWeight
|
~58 kDa
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
|
|
gptkbp:PDB
|
gptkb:1T5A
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
acetylation
|
|
gptkbp:regulates
|
inhibited by ATP
inhibited by alanine
allosterically regulated by fructose-1,6-bisphosphate
|
|
gptkbp:reviewedBy
|
gptkb:Cell_Metabolism
gptkb:Nature_Reviews_Cancer
|
|
gptkbp:roleInCancer
|
promotes aerobic glycolysis
supports Warburg effect
|
|
gptkbp:structureType
|
dimer
tetramer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P14618-2
|
|
gptkbp:bfsParent
|
gptkb:PKM2
|
|
gptkbp:bfsLayer
|
7
|