|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:fructose_1,6-bisphosphate
|
|
gptkbp:alternativeSplicing
|
gptkb:PKM1_and_PKM2_isoforms
|
|
gptkbp:catalyzes
|
conversion of phosphoenolpyruvate to pyruvate
transfer of phosphate group from phosphoenolpyruvate to ADP
|
|
gptkbp:cofactor
|
K+
Mg2+
|
|
gptkbp:deficiencyCauses
|
gptkb:anemia
|
|
gptkbp:discoveredBy
|
1940s
|
|
gptkbp:EC_number
|
2.7.1.40
|
|
gptkbp:enzymeClassification
|
kinase
transferase
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
erythrocytes
|
|
gptkbp:foundIn
|
gptkb:cytoplasm
|
|
gptkbp:gene
|
gptkb:PKM
gptkb:PKLR
gptkb:PKM1
gptkb:PKM2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
pyruvate kinase
|
|
gptkbp:inhibitedBy
|
gptkb:ATP
acetyl-CoA
alanine
phosphoenolpyruvate (feedback inhibition in some species)
long-chain fatty acids
|
|
gptkbp:involves
|
energy metabolism
|
|
gptkbp:molecularWeight
|
~57 kDa (per subunit)
|
|
gptkbp:mutationAssociatedWith
|
hereditary nonspherocytic hemolytic anemia
|
|
gptkbp:pathway
|
glycolysis
|
|
gptkbp:PDB
|
gptkb:1PKN
gptkb:3GR4
|
|
gptkbp:presentIn
|
gptkb:Bacteria
animals
humans
plants
|
|
gptkbp:product
|
gptkb:ATP
gptkb:pyruvate
|
|
gptkbp:regulates
|
allosteric
|
|
gptkbp:significance
|
pyruvate kinase deficiency
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:substrate
|
gptkb:ADP
phosphoenolpyruvate
|
|
gptkbp:systematicName
|
gptkb:ATP:pyruvate_2-O-phosphotransferase
|
|
gptkbp:type
|
phosphoryl transfer
|
|
gptkbp:UniProtID
|
gptkb:P14618_(human_PKLR)
gptkb:P14618_(human_PKM)
|
|
gptkbp:used_in
|
diagnosis of hemolytic anemia
|
|
gptkbp:bfsParent
|
gptkb:Warburg_effect
|
|
gptkbp:bfsLayer
|
5
|