|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:allostericallyRegulatedBy
|
fructose-1,6-bisphosphate
|
|
gptkbp:alsoKnownAs
|
gptkb:PKM2
|
|
gptkbp:alternativeSplicing
|
gptkb:PKM1_and_PKM2_isoforms
|
|
gptkbp:catalyzes
|
conversion of phosphoenolpyruvate to pyruvate
|
|
gptkbp:cofactor
|
K+
Mg2+
|
|
gptkbp:encodedBy
|
gptkb:PKM_gene
|
|
gptkbp:Entrez_Gene_ID
|
5315
|
|
gptkbp:enzymeCommissionNumber
|
2.7.1.40
|
|
gptkbp:expressedIn
|
cancer cells
proliferating cells
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
M2-type pyruvate kinase
|
|
gptkbp:inhibitedBy
|
alanine
phenylalanine
phosphotyrosine proteins
|
|
gptkbp:involvedIn
|
gptkb:Warburg_effect
aerobic glycolysis
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15q23
|
|
gptkbp:molecularWeight
|
~58 kDa
|
|
gptkbp:OMIM
|
609293
|
|
gptkbp:PDB
|
3BJF
|
|
gptkbp:produces
|
gptkb:ATP
|
|
gptkbp:regulates
|
glycolysis
metabolic reprogramming in cancer
|
|
gptkbp:significance
|
biomarker for cancer
|
|
gptkbp:structure
|
tetramer or dimer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P14618
|
|
gptkbp:bfsParent
|
gptkb:PKM2
|
|
gptkbp:bfsLayer
|
7
|