|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:phosphatidylinositol_3,4,5-trisphosphate
calcium
phosphatidylserine
diacylglycerol
|
|
gptkbp:alternativeName
|
gptkb:PRKCI
gptkb:PKCĪ¹
Protein kinase C iota type
|
|
gptkbp:domain
|
gptkb:C1_domain
kinase domain
PB1 domain
|
|
gptkbp:encodedBy
|
PRKCI gene
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:familyMember
|
gptkb:protein_kinase_C_family
|
|
gptkbp:function
|
signal transduction
serine/threonine kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PKC iota
|
|
gptkbp:inhibitedBy
|
gptkb:PSI
ICA-1
aurothiomalate
|
|
gptkbp:interactsWith
|
gptkb:Akt
gptkb:Par-6
gptkb:Rac1
gptkb:p62/SQSTM1
gptkb:Par-3
Lgl
|
|
gptkbp:involvedIn
|
cell proliferation
cell survival
cell polarity
tumorigenesis
|
|
gptkbp:involves
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes
|
|
gptkbp:locale
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
chromosome 3q26.2
|
|
gptkbp:memberOf
|
atypical PKC subfamily
|
|
gptkbp:molecularWeight
|
74 kDa
|
|
gptkbp:orthologInMouse
|
Prkci
|
|
gptkbp:phosphorylates
|
Ser510
Ser555
Thr403
various protein substrates
|
|
gptkbp:regulates
|
gptkb:NF-kappaB_pathway
apoptosis
cell migration
|
|
gptkbp:structure
|
single polypeptide chain
|
|
gptkbp:UniProtID
|
gptkb:Q04759
|
|
gptkbp:bfsParent
|
gptkb:PKC
|
|
gptkbp:bfsLayer
|
6
|