|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
calcium ions
diacylglycerol
|
|
gptkbp:alsoKnownAs
|
PKC family
|
|
gptkbp:atypicalPKCsRequire
|
neither calcium nor diacylglycerol
|
|
gptkbp:conventionalPKCsRequire
|
calcium
|
|
gptkbp:discoveredBy
|
gptkb:Yasutomi_Nishizuka
|
|
gptkbp:EC_number
|
2.7.11.13
|
|
gptkbp:firstDescribed
|
1977
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
serine/threonine kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
protein kinase C family
|
|
gptkbp:involvedIn
|
signal transduction
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
neurodegenerative diseases
|
|
gptkbp:member
|
gptkb:PRKCA
gptkb:PRKCB
gptkb:PRKCD
gptkb:PRKCE
gptkb:PRKCG
gptkb:PRKCH
gptkb:PRKCI
gptkb:PRKCZ
PRKCN
|
|
gptkbp:novelPKCsRequire
|
diacylglycerol
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
gene expression
cytoskeletal remodeling
membrane function
|
|
gptkbp:subspecies
|
atypical PKCs
conventional PKCs
novel PKCs
|
|
gptkbp:target
|
phorbol esters
therapeutic drugs
|
|
gptkbp:bfsParent
|
gptkb:PKCĪ±
gptkb:PKC_alpha
gptkb:PKC_beta
gptkb:PKC_delta
gptkb:PKC_epsilon
gptkb:PKC_eta
gptkb:PKC_gamma
gptkb:PKC_iota
gptkb:PKC_theta
gptkb:PKC_zeta
gptkb:PRKCB
gptkb:PRKCD
gptkb:PRKCE
gptkb:PRKCG
gptkb:PRKCH
gptkb:PRKCI
gptkb:PRKCZ
gptkb:Q02156_(PKC_epsilon)
|
|
gptkbp:bfsLayer
|
7
|