|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
calcium
phosphatidylserine
diacylglycerol
|
|
gptkbp:alternativeName
|
gptkb:PKCι
PKC-iota
Protein kinase C iota type
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
pancreatic cancer
|
|
gptkbp:encodedBy
|
PRKCI gene
|
|
gptkbp:Entrez_Gene_ID
|
5584
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.13
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:function
|
signal transduction
serine/threonine kinase activity
|
|
gptkbp:HGNC_ID
|
9400
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PKCι
|
|
gptkbp:inhibitedBy
|
ATM
ICA-1
aurothiomalate
|
|
gptkbp:interactsWith
|
gptkb:Par-6
gptkb:CDC42
gptkb:Rac1
gptkb:Par-3
Lgl
|
|
gptkbp:involvedIn
|
cell proliferation
cell survival
cell polarity
tumorigenesis
|
|
gptkbp:locale
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
3q26.2
|
|
gptkbp:memberOf
|
atypical PKC subfamily
Protein kinase C family
|
|
gptkbp:OMIM
|
605437
|
|
gptkbp:orthologInMouse
|
Prkci
|
|
gptkbp:phosphorylates
|
various protein substrates
|
|
gptkbp:RefSeq
|
NP_002730.2
|
|
gptkbp:structure
|
contains kinase domain
contains C1 domain
contains PB1 domain
|
|
gptkbp:UniProtID
|
P41743
|
|
gptkbp:bfsParent
|
gptkb:PKC_iota
|
|
gptkbp:bfsLayer
|
7
|