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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_alpha
gptkb:p110_alpha
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:PIK3CA-related_overgrowth_spectrum
gptkb:endometrial_cancer
colorectal cancer
|
|
gptkbp:discoveredBy
|
Kazuo Sugimoto et al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000121879
5290
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
gptkb:catalytic_subunit_of_PI3K_alpha
phosphorylates phosphatidylinositol-4,5-bisphosphate
|
|
gptkbp:HGNC_ID
|
8975
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIK3CA (human)
|
|
gptkbp:interactsWith
|
gptkb:EGFR
gptkb:PIK3R1
gptkb:RAS
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3q26.32
|
|
gptkbp:mutationAssociatedWith
|
oncogenic
E542K
E545K
H1047R
|
|
gptkbp:OMIM
|
171834
|
|
gptkbp:orthologInMouse
|
gptkb:Pik3ca
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:product
|
gptkb:p110α
|
|
gptkbp:UniProtID
|
gptkb:P42336
|
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gptkbp:bfsParent
|
gptkb:Pik3ca
|
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gptkbp:bfsLayer
|
6
|