programmed cell death protein 1 (PD-1)

URI: https://gptkb.org/entity/programmed_cell_death_protein_1_(PD-1)
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
immunotherapy
gptkbp:alternativeName gptkb:PD1
gptkb:CD279
gptkbp:binds gptkb:PD-L2
PD-L1
gptkbp:discoveredBy gptkb:Tasuku_Honjo
gptkbp:discoveredIn 1992
gptkbp:encodedBy gptkb:PDCD1_gene
gptkbp:Entrez_Gene_ID 5133
ENSG00000188389
gptkbp:expressedIn gptkb:B_cells
gptkb:T_cells
dendritic cells
monocytes
gptkbp:foundIn humans
mice
gptkbp:function inhibits immune response
prevents autoimmunity
gptkbp:HGNC_ID 8765
https://www.w3.org/2000/01/rdf-schema#label programmed cell death protein 1 (PD-1)
gptkbp:involvedIn immunotherapy
immune tolerance
gptkbp:locatedOn cell surface
gptkbp:locatedOnChromosome 2q37.3
gptkbp:modulatedBy T cell activity
B cell activity
immune exhaustion
gptkbp:molecularWeight 55 kDa
gptkbp:OMIM 600244
gptkbp:PDB 3RRQ
5GGS
5JXE
gptkbp:phosphorylates gptkb:ITIM
ITSM
gptkbp:relatedTo autoimmune diseases
chronic infections
tumor immune evasion
gptkbp:structure type I transmembrane protein
gptkbp:target gptkb:anti-PD-1_antibodies
gptkb:camrelizumab
gptkb:sintilimab
gptkb:tislelizumab
gptkb:toripalimab
gptkb:pembrolizumab
gptkb:cemiplimab
gptkb:nivolumab
gptkbp:UniProtID Q15116
gptkbp:bfsParent gptkb:Keytruda
gptkbp:bfsLayer 5