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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ERBB
Proto-oncogene c-ErbB-1
Receptor tyrosine-protein kinase ErbB-1
|
|
gptkbp:associatedWith
|
gptkb:Head_and_neck_cancer
gptkb:Glioblastoma
gptkb:Colorectal_cancer
gptkb:Non-small_cell_lung_cancer
Breast cancer
|
|
gptkbp:component
|
gptkb:plasma_membrane
integral component of membrane
|
|
gptkbp:ensemblId
|
gptkb:ENSG00000146648
|
|
gptkbp:Entrez_Gene_ID
|
1956
|
|
gptkbp:family
|
EGFR subfamily
Protein kinase superfamily
Tyr protein kinase family
|
|
gptkbp:function
|
protein tyrosine kinase activity
Tyrosine kinase activity
Receptor for members of the epidermal growth factor family
|
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gptkbp:gene
|
gptkb:EGFR
|
|
gptkbp:GOProcess
|
cell proliferation
signal transduction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P09056
|
|
gptkbp:length
|
1210
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p11.2
|
|
gptkbp:molecularWeight
|
134277 Da
|
|
gptkbp:mutationAssociatedWith
|
gptkb:L858R
gptkb:T790M
Exon 19 deletion
G719S
S768I
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:ErbB_signaling_pathway
|
|
gptkbp:PDB
|
1M17
2GS6
2ITX
3POZ
4HJO
|
|
gptkbp:postTranslationalModification
|
Phosphorylation
Glycosylation
|
|
gptkbp:protein_name
|
gptkb:Epidermal_growth_factor_receptor
|
|
gptkbp:RefSeq
|
NP_005219.2
|
|
gptkbp:sequenceStatus
|
Reviewed
|
|
gptkbp:sequenceVersion
|
4
|
|
gptkbp:subcellularLocation
|
gptkb:Endosome
gptkb:Nucleus
gptkb:Cell_membrane
|
|
gptkbp:targetOfDrug
|
gptkb:Afatinib
gptkb:Erlotinib
gptkb:Gefitinib
gptkb:Osimertinib
Cetuximab
|
|
gptkbp:UniProtID
|
gptkb:P09056
|
|
gptkbp:bfsParent
|
gptkb:mouse_LIF
|
|
gptkbp:bfsLayer
|
8
|