|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ER-alpha
gptkb:NR3A1
Estradiol receptor
|
|
gptkbp:associatedWith
|
gptkb:Endometrial_cancer
Osteoporosis
Breast cancer
|
|
gptkbp:biologicalProcess
|
transcription factor activity
DNA-binding
steroid hormone receptor activity
|
|
gptkbp:EC_number
|
2.3.1.-
|
|
gptkbp:ensemblId
|
gptkb:ENSG00000091831
|
|
gptkbp:Entrez_Gene_ID
|
2099
|
|
gptkbp:function
|
Nuclear hormone receptor
|
|
gptkbp:gene
|
gptkb:ESR1
|
|
gptkbp:goId
|
GO:0005634
GO:0006355
GO:0003707
GO:0004879
|
|
gptkbp:hasIsoform
|
ER-alpha 36
ER-alpha 46
ER-alpha 66
|
|
gptkbp:HGNC_ID
|
3467
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P03372
|
|
gptkbp:interactsWith
|
gptkb:CREBBP
gptkb:EP300
gptkb:GATA3
gptkb:FOXA1
gptkb:BRCA1
gptkb:NCOA2
gptkb:SRC-1
AR
GREB1
|
|
gptkbp:length
|
595
|
|
gptkbp:ligand
|
gptkb:Estradiol
Tamoxifen
Raloxifene
|
|
gptkbp:locatedOnChromosome
|
6q25.1
|
|
gptkbp:mimNumber
|
133430
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
Breast cancer pathway
Estrogen signaling pathway
|
|
gptkbp:PDB
|
1A52
3ERT
1ERE
|
|
gptkbp:pharmgkbId
|
PA134865111
|
|
gptkbp:postTranslationalModification
|
Phosphorylation
Ubiquitination
Sumoylation
|
|
gptkbp:protein_name
|
gptkb:Estrogen_receptor
|
|
gptkbp:RefSeq
|
NP_000116.2
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:subcellularLocation
|
gptkb:Nucleus
gptkb:Cytoplasm
Plasma membrane
|
|
gptkbp:tissue_specificity
|
gptkb:Uterus
gptkb:bone
Breast
Ovary
Prostate
|
|
gptkbp:UniProtID
|
gptkb:P03372
|
|
gptkbp:bfsParent
|
gptkb:Estrogen_receptor
gptkb:ESR1
|
|
gptkbp:bfsLayer
|
7
|