|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ESR
gptkb:ER
gptkb:ER-alpha
gptkb:NR3A1
Estrogen Receptor Alpha
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:bone
gptkb:endometrial_cancer
|
|
gptkbp:discoveredBy
|
gptkb:Elwood_V._Jensen
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:encodes
|
estrogen receptor alpha
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000091831
2099
|
|
gptkbp:expressedIn
|
gptkb:bone
gptkb:prostate
gptkb:testis
uterus
breast tissue
|
|
gptkbp:fullName
|
gptkb:estrogen_receptor_1
|
|
gptkbp:function
|
transcription factor
nuclear receptor
|
|
gptkbp:HGNC_ID
|
3467
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ESR1
|
|
gptkbp:length
|
595 amino acids
|
|
gptkbp:ligand
|
estrogen
|
|
gptkbp:locatedOnChromosome
|
6q25.1
|
|
gptkbp:molecularWeight
|
66 kDa
|
|
gptkbp:mutationAssociatedWith
|
hormone resistance
endocrine therapy resistance
|
|
gptkbp:OMIM
|
133430
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Esr1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
DNA-binding domain
ligand-binding domain
activation function domain
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
gene expression
reproductive system development
|
|
gptkbp:targetOfDrug
|
gptkb:fulvestrant
gptkb:tamoxifen
aromatase inhibitors
raloxifene
|
|
gptkbp:UniProtID
|
gptkb:P03372
|
|
gptkbp:bfsParent
|
gptkb:advanced_hormone_receptor-positive,_HER2-negative_breast_cancer
|
|
gptkbp:bfsLayer
|
6
|