|
gptkbp:instanceOf
|
gptkb:protein
nuclear receptor
|
|
gptkbp:alternativeName
|
gptkb:NR3A1
|
|
gptkbp:binds
|
estrogen
|
|
gptkbp:discoveredBy
|
gptkb:Elwood_V._Jensen
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:encodedBy
|
ESR1 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000091831
|
|
gptkbp:expressedIn
|
gptkb:bone
gptkb:prostate
gptkb:testis
liver
uterus
hypothalamus
breast tissue
|
|
gptkbp:formsHeterodimerWith
|
ER-beta
|
|
gptkbp:fullName
|
gptkb:Estrogen_receptor_alpha
|
|
gptkbp:function
|
transcription factor
mediates estrogen signaling
|
|
gptkbp:gene
|
gptkb:ESR1
|
|
gptkbp:GO
|
GO:0003707
GO:0005496
GO:0030520
|
|
gptkbp:hasIsoform
|
ER-alpha 36
ER-alpha 46
|
|
gptkbp:HGNC_ID
|
3467
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ER-alpha
|
|
gptkbp:locatedOnChromosome
|
6q25.1
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
66 kDa
|
|
gptkbp:OMIM
|
133430
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
ER-beta
|
|
gptkbp:PDB
|
1A52
|
|
gptkbp:phosphorylates
|
Serine 118
Serine 167
|
|
gptkbp:RefSeq
|
gptkb:NM_000125
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
gene expression
|
|
gptkbp:role
|
gptkb:cancer
gptkb:bone
gptkb:endometrial_cancer
|
|
gptkbp:structure
|
contains DNA-binding domain
contains ligand-binding domain
|
|
gptkbp:target
|
gptkb:fulvestrant
gptkb:tamoxifen
raloxifene
|
|
gptkbp:UniProtID
|
gptkb:P03372
|
|
gptkbp:bfsParent
|
gptkb:ESR1
|
|
gptkbp:bfsLayer
|
7
|