|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
calcium signaling
calcineurin
|
|
gptkbp:alternativeName
|
NFAT1
NFATP
NFATp
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:chromosomeArm
|
gptkb:20q13.2
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:encodes
|
NFATC2 protein
|
|
gptkbp:Entrez_Gene_ID
|
4773
ENSG00000131196
|
|
gptkbp:expressedIn
|
gptkb:B_cells
gptkb:T_cells
other immune cells
|
|
gptkbp:fullName
|
Nuclear factor of activated T-cells, cytoplasmic 2
|
|
gptkbp:function
|
transcription factor
regulation of gene expression in immune response
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:7775
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NFATC2
|
|
gptkbp:inhibitedBy
|
gptkb:tacrolimus
cyclosporin A
|
|
gptkbp:interactsWith
|
gptkb:GATA3
gptkb:FOXP3
gptkb:AP-1
calcineurin
|
|
gptkbp:involves
|
T-cell activation
cytokine gene expression
|
|
gptkbp:locatedOnChromosome
|
20
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:OMIM
|
600490
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Nfatc2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
dephosphorylation
|
|
gptkbp:proteinFamily
|
NFAT family
|
|
gptkbp:regulates
|
gptkb:IFNG_gene
gptkb:IL2_gene
gptkb:IL4_gene
gptkb:TNF_gene
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:transcription_regulation
|
binds to DNA at NFAT sites
|
|
gptkbp:UniProtID
|
O95644
|
|
gptkbp:bfsParent
|
gptkb:EWSR1
|
|
gptkbp:bfsLayer
|
7
|