|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:IFN-gamma
type II interferon
|
|
gptkbp:alternativeSplicing
|
no
|
|
gptkbp:associatedWith
|
gptkb:chronic_granulomatous_disease
autoimmune diseases
Mendelian susceptibility to mycobacterial disease
|
|
gptkbp:chromosomeArm
|
q
|
|
gptkbp:clinical_test
|
genetic testing for susceptibility to mycobacterial disease
|
|
gptkbp:discoveredBy
|
1980s
|
|
gptkbp:encodes
|
gptkb:interferon_gamma
|
|
gptkbp:Entrez_Gene_ID
|
3458
ENSG00000111537
IFNG
|
|
gptkbp:expressedIn
|
gptkb:natural_killer_cells
T lymphocytes
|
|
gptkbp:fullName
|
interferon gamma gene
|
|
gptkbp:function
|
immune response regulation
cytokine activity
macrophage activation
antiviral response
|
|
gptkbp:Gene_type
|
protein-coding
|
|
gptkbp:GO_term
|
gptkb:GO:0006955_(immune_response)
GO:0005125 (cytokine activity)
|
|
gptkbp:HGNC_ID
|
5438
IFNG
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IFNG gene
|
|
gptkbp:length
|
166 amino acids
|
|
gptkbp:length_(genomic)
|
5.4 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:12q15
12
|
|
gptkbp:location
|
nucleus (gene), extracellular (protein)
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
increased infection susceptibility
|
|
gptkbp:numberOfExons
|
4
|
|
gptkbp:OMIM
|
147570
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ifng
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:Cytokine-cytokine_receptor_interaction
Th1 and Th2 cell differentiation
|
|
gptkbp:product
|
gptkb:interferon_gamma
|
|
gptkbp:proteinFamily
|
type II interferon
|
|
gptkbp:RefSeq
|
NM_000619
NP_000610
|
|
gptkbp:regulates
|
regulated by cytokines
induced by antigen recognition
|
|
gptkbp:UniProtID
|
P01579
|
|
gptkbp:bfsParent
|
gptkb:interferon-gamma
|
|
gptkbp:bfsLayer
|
6
|