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gptkbp:instanceOf
|
gptkb:protein
translation initiation factor
|
|
gptkbp:alternativeName
|
EIF4E
eIF-4E
eukaryotic initiation factor 4E
|
|
gptkbp:associatedWith
|
gptkb:cancer
cell growth
apoptosis regulation
|
|
gptkbp:component
|
eIF4F complex
|
|
gptkbp:discoveredBy
|
Nahum Sonenberg
|
|
gptkbp:discoveredIn
|
1978
|
|
gptkbp:fullName
|
Eukaryotic translation initiation factor 4E
|
|
gptkbp:function
|
binds 5' cap of mRNA
facilitates ribosome recruitment
|
|
gptkbp:gene
|
EIF4E
|
|
gptkbp:GO
|
GO:0003723
GO:0006413
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
eIF4E
|
|
gptkbp:inhibitedBy
|
gptkb:4E-BP1
ribavirin
|
|
gptkbp:interactsWith
|
gptkb:4E-BP1
gptkb:eIF4G
gptkb:eIF4A
|
|
gptkbp:locatedOnChromosome
|
4q24
|
|
gptkbp:molecularWeight
|
~25 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
1EJ1
|
|
gptkbp:phosphorylates
|
gptkb:MNK1
gptkb:MNK2
|
|
gptkbp:regulates
|
phosphorylation
binding by 4E-BPs
|
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gptkbp:requires
|
cap-dependent translation
|
|
gptkbp:structure
|
cap-binding domain
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:UniProtID
|
P06730
|
|
gptkbp:bfsParent
|
gptkb:4EBP1
|
|
gptkbp:bfsLayer
|
6
|