matrix metallopeptidase 13

URI: https://gptkb.org/entity/matrix_metallopeptidase_13
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy proteolytic cleavage
gptkbp:alsoKnownAs gptkb:collagenase_3
gptkbp:associatedWith osteoarthritis
cancer progression
rheumatoid arthritis
gptkbp:encodedBy MMP13 gene
gptkbp:Entrez_Gene_ID 4322
gptkbp:expressedIn gptkb:bone
collagen
synovial tissue
gptkbp:function degradation of extracellular matrix
collagen breakdown
gptkbp:HGNC_ID HGNC:7157
https://www.w3.org/2000/01/rdf-schema#label matrix metallopeptidase 13
gptkbp:involves arthritis
metastasis
tissue remodeling
tumor invasion
gptkbp:locatedIn extracellular matrix
gptkbp:locatedOnChromosome gptkb:chromosome_11q22.3
gptkbp:member gptkb:matrix_metalloproteinase_family
gptkbp:OMIM gptkb:600108
gptkbp:product MMP13 gene
gptkbp:regulates gptkb:tissue_inhibitors_of_metalloproteinases_(TIMPs)
gptkbp:structure contains hemopexin-like domain
contains zinc-binding motif
gptkbp:substrate gptkb:type_I_collagen
type II collagen
type III collagen
gptkbp:UniProtID gptkb:P45452
gptkbp:bfsParent gptkb:MMP13
gptkbp:bfsLayer 7