|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:GIF
glycosylation-inhibiting factor
|
|
gptkbp:associatedWith
|
gptkb:cancer
asthma
sepsis
rheumatoid arthritis
|
|
gptkbp:biologicalProcess
|
cell proliferation
immune response
apoptosis regulation
inflammatory response
|
|
gptkbp:clinicalTrialPhase
|
MIF inhibitors in autoimmune diseases
MIF inhibitors in cancer
|
|
gptkbp:discoveredBy
|
gptkb:John_David
|
|
gptkbp:discoveredIn
|
1966
|
|
gptkbp:encodedBy
|
gptkb:MIF_gene
|
|
gptkbp:enzyme
|
tautomerase
|
|
gptkbp:expressedIn
|
gptkb:pituitary_gland
gptkb:T_cells
various tissues
macrophages
|
|
gptkbp:fullName
|
Macrophage migration inhibitory factor
|
|
gptkbp:function
|
cytokine
regulation of immune response
inhibition of macrophage migration
|
|
gptkbp:gene
|
gptkb:MIF
|
|
gptkbp:GO_term
|
gptkb:GO:0006955_(immune_response)
GO:0006954 (inflammatory response)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MIF protein
|
|
gptkbp:inhibitedBy
|
4-IPP
ISO-1
|
|
gptkbp:locatedOnChromosome
|
22q11.23
|
|
gptkbp:location
|
gptkb:cytoplasm
secreted
|
|
gptkbp:molecularWeight
|
12.5 kDa
|
|
gptkbp:OMIM
|
153620
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus Mif
Rattus norvegicus Mif
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:NF-kappaB_signaling_pathway
|
|
gptkbp:PDB
|
1MFI
|
|
gptkbp:postTranslationalModification
|
N-terminal proline
|
|
gptkbp:recipient
|
gptkb:CD74
gptkb:CXCR2
gptkb:CXCR4
gptkb:CXCR7
|
|
gptkbp:structure
|
homotrimer
|
|
gptkbp:UniProtID
|
P14174
|
|
gptkbp:bfsParent
|
gptkb:Mif
|
|
gptkbp:bfsLayer
|
8
|