MICA gene

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alternativeSplicing yes
gptkbp:associatedWith immune response
gptkbp:biologicalProcess stress-induced ligand for NKG2D
gptkbp:discoveredIn 1994
gptkbp:encodes MICA protein
gptkbp:Entrez_Gene_ID 4276
ENSG00000204516
gptkbp:expressedIn endothelial cells
fibroblasts
epithelial cells
gptkbp:fullName MHC class I polypeptide-related sequence A
gptkbp:hasPolymorphism true
gptkbp:HGNC_ID 7090
https://www.w3.org/2000/01/rdf-schema#label MICA gene
gptkbp:involves gptkb:cancer
autoimmune diseases
transplant rejection
gptkbp:length 383 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_6
6p21.33
gptkbp:memberOf gptkb:major_histocompatibility_complex
gptkbp:OMIM 600179
gptkbp:orthologInMouse no direct ortholog
gptkbp:product transmembrane glycoprotein
gptkbp:proteinFamily gptkb:MHC_class_I_family
gptkbp:proteinWeight 43 kDa
gptkbp:recognizedBy NKG2D receptor
gptkbp:relatedTo gptkb:HLA_genes
gptkb:MICB_gene
gptkbp:UniProtID Q29983
gptkbp:variant gptkb:primary_biliary_cirrhosis
gptkb:Behçet's_disease
gptkb:systemic_lupus_erythematosus
gptkb:Crohn's_disease
gptkb:Hashimoto's_thyroiditis
gptkb:Sjögren's_syndrome
gptkb:systemic_sclerosis
gptkb:graft-versus-host_disease
colorectal cancer
Graves' disease
multiple sclerosis
type 1 diabetes
ulcerative colitis
psoriasis
rheumatoid arthritis
hepatocellular carcinoma
gastric cancer
celiac disease
ankylosing spondylitis
gptkbp:bfsParent gptkb:6p21.3
gptkbp:bfsLayer 7