primary biliary cirrhosis

URI: https://gptkb.org/entity/primary_biliary_cirrhosis

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:liver_disease autoimmune disease
gptkbp:affects	liver
gptkbp:alsoKnownAs	gptkb:primary_biliary_cholangitis
gptkbp:associatedWith	gptkb:CXCR5 gptkb:IRF5 gptkb:STAT4 gptkb:CTLA4 gptkb:CD80 gptkb:IL12A cirrhosis fatigue jaundice pruritus cholestasis hyperlipidemia SPIB HLA-DR8 POU2AF1 TNFSF15 IKZF3
gptkbp:canProgressTo	liver failure
gptkbp:characterizedBy	progressive destruction of intrahepatic bile ducts
gptkbp:commonIn	gptkb:women
gptkbp:complication	gptkb:bone hepatocellular carcinoma portal hypertension
gptkbp:diagnosedBy	liver biopsy antimitochondrial antibodies elevated alkaline phosphatase
gptkbp:firstDescribed	1851 Addison and Gull
gptkbp:guidanceSystem	gptkb:American_Association_for_the_Study_of_Liver_Diseases_(AASLD) gptkb:European_Association_for_the_Study_of_the_Liver_(EASL)
gptkbp:hasAutoantibody	antimitochondrial antibody (AMA)
https://www.w3.org/2000/01/rdf-schema#label	primary biliary cirrhosis
gptkbp:ICD-10_code	K74.3
gptkbp:MeSH_ID	D001665
gptkbp:prevalence	rare
gptkbp:riskFactor	family history other autoimmune diseases
gptkbp:symptom	dry mouth xanthomas dry eyes right upper quadrant pain
gptkbp:treatment	gptkb:ursodeoxycholic_acid liver transplantation obeticolic acid
gptkbp:typicalOnsetAge	30-60 years
gptkbp:bfsParent	gptkb:primary_biliary_cholangitis
gptkbp:bfsLayer	7