|
gptkbp:instanceOf
|
gptkb:autoimmune_disease
gptkb:connective_tissue_disease
gptkb:rare_disease
|
|
gptkbp:affects
|
gptkb:skin
adults
heart
lungs
gastrointestinal tract
kidneys
more common in women
|
|
gptkbp:alsoKnownAs
|
scleroderma
|
|
gptkbp:associatedWith
|
gptkb:anti-RNA_polymerase_III_antibody
gptkb:anti-centromere_antibody
gptkb:anti-topoisomerase_I_antibody
|
|
gptkbp:characterizedBy
|
fibrosis
skin thickening
immune system activation
vascular abnormalities
|
|
gptkbp:complication
|
gptkb:interstitial_lung_disease
pulmonary arterial hypertension
cardiac arrhythmias
malabsorption
renal crisis
|
|
gptkbp:diagnosedBy
|
clinical examination
imaging studies
skin biopsy
autoantibody testing
|
|
gptkbp:firstDescribed
|
gptkb:Carlo_Curzio
1753
|
|
gptkbp:ICD-10_code
|
M34
|
|
gptkbp:prevalence
|
rare
|
|
gptkbp:prognosis
|
variable
|
|
gptkbp:riskFactor
|
family history
female sex
exposure to silica dust
|
|
gptkbp:subspecies
|
gptkb:diffuse_cutaneous_systemic_sclerosis
gptkb:limited_cutaneous_systemic_sclerosis
|
|
gptkbp:symptom
|
gptkb:Raynaud's_phenomenon
joint pain
telangiectasia
muscle weakness
digital ulcers
esophageal dysmotility
|
|
gptkbp:treatment
|
gptkb:proton_pump_inhibitors
physical therapy
corticosteroids
immunosuppressive drugs
vasodilators
|
|
gptkbp:bfsParent
|
gptkb:Primary_Biliary_Cirrhosis
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
systemic sclerosis
|