Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
autoimmune disease
rare disease connective tissue disease |
| gptkbp:affects |
gptkb:skin
adults heart lungs gastrointestinal tract kidneys more common in women |
| gptkbp:alsoKnownAs |
scleroderma
|
| gptkbp:associatedWith |
gptkb:anti-RNA_polymerase_III_antibody
gptkb:anti-centromere_antibody gptkb:anti-topoisomerase_I_antibody |
| gptkbp:characterizedBy |
fibrosis
skin thickening immune system activation vascular abnormalities |
| gptkbp:complication |
interstitial lung disease
pulmonary arterial hypertension cardiac arrhythmias malabsorption renal crisis |
| gptkbp:diagnosedBy |
clinical examination
imaging studies skin biopsy autoantibody testing |
| gptkbp:firstDescribed |
gptkb:Carlo_Curzio
1753 |
| https://www.w3.org/2000/01/rdf-schema#label |
systemic sclerosis
|
| gptkbp:ICD-10_code |
M34
|
| gptkbp:prevalence |
rare
|
| gptkbp:prognosis |
variable
|
| gptkbp:riskFactor |
family history
female sex exposure to silica dust |
| gptkbp:subspecies |
gptkb:diffuse_cutaneous_systemic_sclerosis
gptkb:limited_cutaneous_systemic_sclerosis |
| gptkbp:symptom |
gptkb:Raynaud's_phenomenon
joint pain telangiectasia muscle weakness digital ulcers esophageal dysmotility |
| gptkbp:treatment |
gptkb:proton_pump_inhibitors
physical therapy corticosteroids immunosuppressive drugs vasodilators |
| gptkbp:bfsParent |
gptkb:Primary_Biliary_Cirrhosis
|
| gptkbp:bfsLayer |
6
|