|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:LKB1
|
|
gptkbp:associatedSyndrome
|
gptkb:Peutz-Jeghers_syndrome
|
|
gptkbp:clinicalTrialPhase
|
available
|
|
gptkbp:discoveredBy
|
gptkb:Hemminki_et_al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodes
|
gptkb:serine/threonine_kinase_11
|
|
gptkbp:Entrez_Gene_ID
|
6794
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
gptkb:tumor_suppressor
regulation of cell cycle
regulation of metabolism
regulation of cell polarity
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
11389
|
|
gptkbp:inheritance
|
autosomal dominant
|
|
gptkbp:interactsWith
|
MO25
STRAD
|
|
gptkbp:length
|
433 amino acids
23,000 base pairs
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
gptkb:chromosome_19
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Peutz-Jeghers_syndrome
pancreatic cancer
nonsense
missense
frameshift
splice site
|
|
gptkbp:OMIM
|
602216
|
|
gptkbp:orthologInMouse
|
gptkb:Stk11
|
|
gptkbp:orthologInZebrafish
|
gptkb:stk11a
|
|
gptkbp:proteinFamily
|
tumor suppressor genes
protein kinase domain
N-terminal domain
serine/threonine protein kinases
C-terminal regulatory domain
|
|
gptkbp:proteinKinaseActivity
|
yes
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:AMPK_pathway
gptkb:mTOR_pathway
apoptosis
cell migration
cell polarity
cellular energy homeostasis
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:UniProtID
|
Q15831
|
|
gptkbp:bfsParent
|
gptkb:Peutz-Jeghers_syndrome
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
STK11 gene
|