indoleamine 2,3-dioxygenase (IDO)

URI: https://gptkb.org/entity/indoleamine_2,3-dioxygenase_(IDO)
GPTKB entity
Statements (36)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:IDO1
gptkb:indoleamine-pyrrole_2,3-dioxygenase
gptkbp:associatedWith gptkb:cancer
infectious diseases
autoimmune diseases
gptkbp:catalyzes oxidation of tryptophan to N-formylkynurenine
gptkbp:cofactor hemoglobin
gptkbp:EC_number 1.13.11.52
gptkbp:expressedIn gptkb:placenta
dendritic cells
macrophages
gptkbp:firstDescribed 1967
gptkbp:foundIn humans
mammals
gptkbp:gene gptkb:IDO1
https://www.w3.org/2000/01/rdf-schema#label indoleamine 2,3-dioxygenase (IDO)
gptkbp:inducedBy gptkb:interferon-gamma
gptkbp:inhibitedBy gptkb:epacadostat
1-methyl-tryptophan
gptkbp:involves kynurenine pathway
tryptophan catabolism
gptkbp:locatedOnChromosome 8p11.21 (human)
gptkbp:molecularWeight 45 kDa
gptkbp:orthologIn gptkb:mouse
right
gptkbp:PDB gptkb:2D0T
gptkbp:regulates immune response
gptkbp:role tumor immune evasion
maternal-fetal tolerance
gptkbp:structure monomeric protein
gptkbp:UniProtID P14902
gptkbp:bfsParent gptkb:Kynurenine_pathway
gptkb:indoximod
gptkb:1QMT
gptkbp:bfsLayer 8