indoleamine 2,3-dioxygenase (IDO)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:alternativeName	gptkb:IDO1 gptkb:indoleamine-pyrrole_2,3-dioxygenase
gptkbp:associatedWith	gptkb:cancer infectious diseases autoimmune diseases
gptkbp:catalyzes	oxidation of tryptophan to N-formylkynurenine
gptkbp:cofactor	gptkb:hemoglobin
gptkbp:EC_number	1.13.11.52
gptkbp:expressedIn	gptkb:placenta dendritic cells macrophages
gptkbp:firstDescribed	1967
gptkbp:foundIn	humans mammals
gptkbp:gene	gptkb:IDO1
gptkbp:inducedBy	gptkb:interferon-gamma
gptkbp:inhibitedBy	gptkb:epacadostat 1-methyl-tryptophan
gptkbp:involves	kynurenine pathway tryptophan catabolism
gptkbp:locatedOnChromosome	8p11.21 (human)
gptkbp:molecularWeight	45 kDa
gptkbp:orthologIn	gptkb:mouse gptkb:right
gptkbp:PDB	gptkb:2D0T
gptkbp:regulates	gptkb:immune_response
gptkbp:role	tumor immune evasion maternal-fetal tolerance
gptkbp:structure	monomeric protein
gptkbp:UniProtID	P14902
gptkbp:bfsParent	gptkb:Kynurenine_pathway gptkb:indoximod
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	indoleamine 2,3-dioxygenase (IDO)