tryptophan 2,3-dioxygenase (TDO)
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:tryptophan_pyrrolase
gptkb:TDO L-tryptophan 2,3-oxidase |
| gptkbp:catalyzes |
oxidation of L-tryptophan to N-formylkynurenine
|
| gptkbp:cofactor |
hemoglobin
|
| gptkbp:EC_number |
1.13.11.11
|
| gptkbp:foundIn |
mammals
liver |
| gptkbp:gene |
gptkb:TDO2
|
| https://www.w3.org/2000/01/rdf-schema#label |
tryptophan 2,3-dioxygenase (TDO)
|
| gptkbp:inhibitedBy |
inhibited by nitric oxide
|
| gptkbp:pathway |
kynurenine pathway
|
| gptkbp:product |
N-formylkynurenine
|
| gptkbp:regulates |
induced by glucocorticoids
inhibited by tryptophan |
| gptkbp:role |
involved in NAD+ biosynthesis
regulates tryptophan levels |
| gptkbp:structure |
homotetramer
|
| gptkbp:substrate |
L-tryptophan
|
| gptkbp:UniProtID |
P48775 (human)
|
| gptkbp:bfsParent |
gptkb:Kynurenine_pathway
|
| gptkbp:bfsLayer |
8
|