|
gptkbp:instanceOf
|
gptkb:protein
gptkb:drug
cytokine
|
|
gptkbp:administeredBy
|
injection
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
L03AB04
|
|
gptkbp:CASNumber
|
76543-88-9
|
|
gptkbp:category
|
antiviral drug
immunotherapy
|
|
gptkbp:contraindication
|
autoimmune hepatitis
decompensated liver disease
severe psychiatric disorders
|
|
gptkbp:developedBy
|
gptkb:Hoffmann-La_Roche
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:eliminationHalfLife
|
3-8 hours
|
|
gptkbp:gene
|
IFNA2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Interferon alfa-2a
|
|
gptkbp:interactsWith
|
gptkb:zidovudine
ribavirin
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
gptkb:Roferon-A
|
|
gptkbp:mechanismOfAction
|
inhibits viral replication
modulates immune response
|
|
gptkbp:molecularWeight
|
19237 Da
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:producedBy
|
recombinant DNA technology
|
|
gptkbp:proteinSequence
|
identical to human interferon alpha-2a
|
|
gptkbp:routeOfAdministration
|
intramuscular
subcutaneous
|
|
gptkbp:sideEffect
|
gptkb:depression
gptkb:anemia
fatigue
neutropenia
thrombocytopenia
flu-like symptoms
|
|
gptkbp:UNII
|
P0A3F4ZL5D
|
|
gptkbp:usedFor
|
gptkb:chronic_myelogenous_leukemia
gptkb:hairy_cell_leukemia
gptkb:hepatitis_C
gptkb:Kaposi's_sarcoma
gptkb:hepatitis_B
leukemia
|
|
gptkbp:bfsParent
|
gptkb:DB00021
|
|
gptkbp:bfsLayer
|
7
|