|
gptkbp:instanceOf
|
gptkb:protein
cytokine
|
|
gptkbp:alternativeName
|
gptkb:CXCL8
gptkb:Interleukin-8
|
|
gptkbp:associatedWith
|
gptkb:cancer
asthma
chronic obstructive pulmonary disease
rheumatoid arthritis
cystic fibrosis
|
|
gptkbp:discoveredBy
|
Yoshimura et al.
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:Entrez_Gene_ID
|
3576
ENSG00000169429
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
inflammatory response
chemotaxis
neutrophil activation
|
|
gptkbp:gene
|
gptkb:CXCL8
|
|
gptkbp:GO_term
|
gptkb:GO:0005125
GO:0008009
|
|
gptkbp:HGNC_ID
|
6025
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL8
|
|
gptkbp:inhibitedBy
|
gptkb:glucocorticoids
|
|
gptkbp:involvedIn
|
angiogenesis
cancer progression
immune response
acute inflammation
|
|
gptkbp:length
|
99
|
|
gptkbp:locatedOnChromosome
|
4q13-q21
|
|
gptkbp:molecularWeight
|
11 kDa
|
|
gptkbp:OMIM
|
146930
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
chemokine signaling pathway
NF-kappa B signaling pathway
|
|
gptkbp:PDB
|
1IL8
|
|
gptkbp:postTranslationalModification
|
glycosylation
N-terminal truncation
|
|
gptkbp:promotion
|
gptkb:IL-1
gptkb:TNF-alpha
bacterial products
|
|
gptkbp:recipient
|
gptkb:CXCR2
gptkb:CXCR1
|
|
gptkbp:secretes
|
macrophages
endothelial cells
epithelial cells
|
|
gptkbp:significance
|
biomarker for inflammation
target for anti-inflammatory drugs
|
|
gptkbp:structure
|
dimer
monomer
|
|
gptkbp:UniProtID
|
P10145
|
|
gptkbp:bfsParent
|
gptkb:Il-86
gptkb:IL86
|
|
gptkbp:bfsLayer
|
6
|