Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:alsoKnownAs |
gptkb:CXCL8
gptkb:IL-8 |
| gptkbp:binds |
glycosaminoglycans
|
| gptkbp:discoveredIn |
1987
|
| gptkbp:encodedBy |
gptkb:CXCL8_gene
|
| gptkbp:Entrez_Gene_ID |
3576
|
| gptkbp:family |
CXC chemokine family
|
| gptkbp:function |
inflammatory response
chemotaxis of neutrophils |
| https://www.w3.org/2000/01/rdf-schema#label |
Interleukin-8
|
| gptkbp:involvedIn |
wound healing
angiogenesis cancer progression chronic inflammation acute inflammation |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_4q13-q21
|
| gptkbp:molecularWeight |
8 kDa
|
| gptkbp:OMIM |
146930
|
| gptkbp:PDB |
1IL8
|
| gptkbp:producedBy |
macrophages
endothelial cells epithelial cells |
| gptkbp:promotion |
gptkb:IL-1
gptkb:TNF-alpha bacterial products |
| gptkbp:recipient |
gptkb:CXCR2
gptkb:CXCR1 |
| gptkbp:role |
respiratory burst
activation of neutrophils promotion of phagocytosis recruitment of immune cells release of enzymes from neutrophils |
| gptkbp:secretes |
gptkb:T_cells
gptkb:keratinocytes fibroblasts monocytes |
| gptkbp:significance |
marker of inflammation
elevated in asthma elevated in cancer elevated in rheumatoid arthritis elevated in sepsis |
| gptkbp:structure |
dimer
monomer |
| gptkbp:target |
CXCR1 antagonists
CXCR2 antagonists anti-IL-8 antibodies |
| gptkbp:UniProtID |
P10145
|
| gptkbp:bfsParent |
gptkb:P15391
gptkb:P84077 gptkb:IL8 |
| gptkbp:bfsLayer |
7
|