IL-6 family cytokine signaling
GPTKB entity
Statements (44)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway gptkb:JAK/STAT_pathway |
| gptkbp:cause |
gene expression changes
STAT1 activation STAT3 activation |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
autoimmune diseases chronic inflammation |
| https://www.w3.org/2000/01/rdf-schema#label |
IL-6 family cytokine signaling
|
| gptkbp:involves |
gptkb:CLC
gptkb:CT-1 gptkb:OSM gptkb:LIF gptkb:IL-6 gptkb:CNTF gptkb:IL-27 IL-31 IL-11 |
| gptkbp:launched |
cytokine binding
|
| gptkbp:location |
gptkb:cell_membrane
gptkb:nucleus gptkb:cytoplasm |
| gptkbp:modulatedBy |
gptkb:PIAS_proteins
gptkb:SOCS_proteins gptkb:protein_tyrosine_phosphatases |
| gptkbp:receptorComplex |
gptkb:gp130
|
| gptkbp:receptorComponent |
gptkb:LIFR
gptkb:gp130 gptkb:IL-6R gptkb:OSMR CNTFR IL-11R IL-31RA WSX-1 |
| gptkbp:regulates |
cell proliferation
cell survival inflammation immune response hematopoiesis acute phase response |
| gptkbp:bfsParent |
gptkb:gp130
|
| gptkbp:bfsLayer |
7
|