|
gptkbp:instanceOf
|
gptkb:protein
cytokine
|
|
gptkbp:approvedBy
|
gptkb:chronic_granulomatous_disease
severe malignant osteopetrosis
|
|
gptkbp:approvedDrugName
|
Interferon gamma-1b
|
|
gptkbp:associatedWith
|
autoimmune diseases
inflammatory diseases
|
|
gptkbp:discoveredBy
|
E. F. Wheelock
|
|
gptkbp:discoveredIn
|
1965
|
|
gptkbp:expressedIn
|
gptkb:natural_killer_cells
activated T lymphocytes
|
|
gptkbp:fullName
|
Interferon gamma
|
|
gptkbp:function
|
immune response regulation
antiviral activity
activation of macrophages
promotion of antigen presentation
|
|
gptkbp:gene
|
IFNG
|
|
gptkbp:GOID
|
GO:0005132
|
|
gptkbp:halfLife
|
~30 minutes (in plasma)
|
|
gptkbp:HGNC_ID
|
5438
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IFN-γ
|
|
gptkbp:inducedBy
|
MHC class II expression
|
|
gptkbp:inhibitedBy
|
gptkb:IL-4
gptkb:TGF-β
viral replication
Th2 cell proliferation
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12_(human)
|
|
gptkbp:measures
|
gptkb:ELISA
gptkb:ELISPOT
flow cytometry
|
|
gptkbp:molecularWeight
|
~17 kDa (monomer)
|
|
gptkbp:OMIM
|
147570
|
|
gptkbp:PDB
|
1FG9
|
|
gptkbp:producedBy
|
gptkb:NK_cells
gptkb:T_cells
|
|
gptkbp:promotion
|
gptkb:IL-12
gptkb:IL-18
antigen presentation
macrophage activation
antigen processing
|
|
gptkbp:recipient
|
IFN-γ receptor
|
|
gptkbp:regulates
|
gptkb:Th1_immune_response
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:target
|
therapeutic antibodies
JAK inhibitors
|
|
gptkbp:UniProtID
|
P01579
|
|
gptkbp:usedIn
|
immunotherapy
diagnostic tests
|
|
gptkbp:bfsParent
|
gptkb:interferon-gamma
|
|
gptkbp:bfsLayer
|
6
|