|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:HIF
|
|
gptkbp:activatedBy
|
low oxygen levels
|
|
gptkbp:binds
|
gptkb:hypoxia_response_elements_(HREs)
|
|
gptkbp:category
|
transcription factor
|
|
gptkbp:composedOf
|
gptkb:HIF-1α
gptkb:HIF-1β
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredBy
|
gptkb:Gregg_L._Semenza
|
|
gptkbp:form
|
heterodimer
|
|
gptkbp:function
|
regulation of gene expression in response to hypoxia
|
|
gptkbp:gene
|
gptkb:EPAS1
gptkb:HIF1A
gptkb:HIF3A
|
|
gptkbp:GO_term
|
GO:0001666 (response to hypoxia)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hypoxia-inducible factor
|
|
gptkbp:inhibitedBy
|
normoxia
|
|
gptkbp:locatedIn
|
gptkb:nucleus
|
|
gptkbp:MeSH_ID
|
D054856
|
|
gptkbp:NobelPrizeYear
|
gptkb:Gregg_L._Semenza
gptkb:Peter_J._Ratcliffe
gptkb:William_Kaelin_Jr.
gptkb:2019_Physiology_or_Medicine
|
|
gptkbp:OMIM
|
gptkb:603348_(HIF1A)
gptkb:603349_(EPAS1)
gptkb:610426_(HIF3A)
|
|
gptkbp:regulates
|
gptkb:erythropoietin_gene
gptkb:VEGF_gene
gptkb:GLUT1_gene
genes involved in angiogenesis
genes involved in cell survival
genes involved in metabolism
|
|
gptkbp:regulationMechanism
|
prolyl hydroxylation
|
|
gptkbp:relatedTo
|
cancer progression
chronic kidney disease
ischemic diseases
|
|
gptkbp:studiedIn
|
humans
mammals
mice
|
|
gptkbp:subunit
|
gptkb:HIF-1α
gptkb:HIF-1β
gptkb:HIF-2α
gptkb:HIF-3α
|
|
gptkbp:target
|
therapeutic drugs
|
|
gptkbp:ubiquitinatedBy
|
gptkb:VHL_protein
|
|
gptkbp:UniProtID
|
Q16665 (HIF-1α)
Q99814 (HIF-2α)
Q9Y2N7 (HIF-3α)
|
|
gptkbp:bfsParent
|
gptkb:HIF
|
|
gptkbp:bfsLayer
|
7
|