|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BHLHE78
gptkb:MOP1
gptkb:PASD8
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:erythrocytosis
ischemia
|
|
gptkbp:component
|
gptkb:nucleus
|
|
gptkbp:degradedBy
|
VHL-mediated ubiquitination
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodes
|
gptkb:hypoxia-inducible_factor_1-alpha
|
|
gptkbp:Entrez_Gene_ID
|
3091
ENSG00000100644
|
|
gptkbp:formsHeterodimerWith
|
gptkb:ARNT
|
|
gptkbp:function
|
transcription factor
DNA binding
transcriptional activator activity
|
|
gptkbp:gene
|
gptkb:HIF1A
|
|
gptkbp:GOProcess
|
cellular response to hypoxia
|
|
gptkbp:HGNC_ID
|
HGNC:4910
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
603348 (HIF1A)
|
|
gptkbp:involvedIn
|
angiogenesis
metabolic adaptation
response to hypoxia
|
|
gptkbp:length
|
826 amino acids
|
|
gptkbp:locatedOnChromosome
|
14q23.2
|
|
gptkbp:molecularWeight
|
93 kDa
|
|
gptkbp:mutationAssociatedWith
|
familial erythrocytosis type 4
|
|
gptkbp:OMIM
|
603348
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hif1a
|
|
gptkbp:orthologInZebrafish
|
hif1aa
|
|
gptkbp:pathway
|
angiogenesis
glycolysis
HIF-1 signaling pathway
|
|
gptkbp:PDB
|
1H2M
4H6J
1L3E
|
|
gptkbp:phosphorylates
|
regulates stability
|
|
gptkbp:product
|
gptkb:HIF-1α
|
|
gptkbp:regulates
|
gptkb:LDHA
gptkb:EPO
gptkb:GLUT1
gptkb:VEGF
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q16665
|
|
gptkbp:bfsParent
|
gptkb:Hypoxia-inducible_factor
|
|
gptkbp:bfsLayer
|
8
|