|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:BiP
gptkb:GRP78
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
|
|
gptkbp:discoveredBy
|
gptkb:Kazutoshi_Mori
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
HSPA5 gene
|
|
gptkbp:Entrez_Gene_ID
|
3309
|
|
gptkbp:expressedIn
|
most tissues
|
|
gptkbp:family
|
gptkb:heat_shock_protein_70_family
|
|
gptkbp:function
|
protein folding
unfolded protein response
molecular chaperone
|
|
gptkbp:GO
|
GO:0034976 (response to endoplasmic reticulum stress)
GO:0006986 (response to unfolded protein)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hspa5
|
|
gptkbp:interactsWith
|
gptkb:ATF6
gptkb:IRE1
gptkb:PERK
|
|
gptkbp:involvedIn
|
protein quality control
ER stress response
|
|
gptkbp:locatedOnChromosome
|
9q33.3
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:marking
|
ER stress
|
|
gptkbp:molecularWeight
|
78 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:5E84
6ASY
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
upregulated by ER stress
regulated by ATF6
regulated by XBP1
|
|
gptkbp:requires
|
cell survival under stress
|
|
gptkbp:sequence
|
654 amino acids
|
|
gptkbp:structure
|
ATPase domain
substrate-binding domain
|
|
gptkbp:UniProtID
|
P11021
|
|
gptkbp:bfsParent
|
gptkb:Bip_(gene)
|
|
gptkbp:bfsLayer
|
6
|