Hsp90 (heat shock protein 90)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein molecular chaperone
gptkbp:alternativeName	gptkb:HSP_90 gptkb:heat_shock_protein_90 gptkb:HSP90 gptkb:HSPC
gptkbp:ATPaseActivity	yes
gptkbp:conservedIn	eukaryotes
gptkbp:discoveredIn	1970s
gptkbp:encodedBy	gptkb:HSP90AA1 gptkb:HSP90AB1 gptkb:HSP90B1
gptkbp:formsComplexWith	client proteins co-chaperones
gptkbp:foundIn	eukaryotic cells
gptkbp:function	signal transduction protein folding protein degradation cellular stress response protein stabilization
https://www.w3.org/2000/01/rdf-schema#label	Hsp90 (heat shock protein 90)
gptkbp:inhibitedBy	gptkb:geldanamycin gptkb:radicicol
gptkbp:interactsWith	gptkb:Hsp70 co-chaperones
gptkbp:locale	gptkb:endoplasmic_reticulum mitochondria cytosol
gptkbp:locatedOnChromosome	chromosome 12 (HSP90B1) chromosome 14 (HSP90AA1) chromosome 6 (HSP90AB1)
gptkbp:molecularWeight	~90 kDa
gptkbp:postTranslationalModification	phosphorylation ubiquitination acetylation
gptkbp:regulates	gptkb:steroid_hormone_receptors gptkb:kinases transcription factors
gptkbp:requires	cell viability
gptkbp:role	gptkb:cancer neurodegenerative diseases protein homeostasis
gptkbp:structure	homodimer middle domain C-terminal dimerization domain N-terminal ATP-binding domain
gptkbp:substrate	client proteins
gptkbp:target	anticancer drugs
gptkbp:bfsParent	gptkb:radicicol
gptkbp:bfsLayer	8