heat shock protein 90 family

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	Hsp90 family
gptkbp:ATPaseActivity	yes
gptkbp:co-chaperone	gptkb:FKBP51 gptkb:FKBP52 gptkb:Hop gptkb:AHA1 gptkb:CDC37 p23 SGT1
gptkbp:conservedIn	gptkb:HSP90 HATPase_c
gptkbp:evolutionaryConservation	high
gptkbp:foundIn	gptkb:Bacteria archaea eukaryotes
gptkbp:function	protein folding cellular stress response molecular chaperone stabilization of proteins
gptkbp:GO_term	gptkb:GO:0006457_(protein_folding) GO:0005515 (protein binding) GO:0006950 (response to stress)
https://www.w3.org/2000/01/rdf-schema#label	heat shock protein 90 family
gptkbp:inhibitedBy	gptkb:geldanamycin gptkb:radicicol
gptkbp:interactsWith	client proteins co-chaperones
gptkbp:locale	gptkb:endoplasmic_reticulum gptkb:nucleus gptkb:cytoplasm mitochondria
gptkbp:member	gptkb:HSP90AA1 gptkb:HSP90AB1 gptkb:HSP90B1
gptkbp:molecularWeight	~90 kDa
gptkbp:requires	development stress tolerance cell viability
gptkbp:role	signal transduction cancer biology protein degradation cell cycle control protein homeostasis
gptkbp:structure	homodimer middle domain C-terminal dimerization domain N-terminal ATP-binding domain
gptkbp:target	anticancer drugs antifungal drugs
gptkbp:bfsParent	gptkb:HSP90B1_gene gptkb:HSP86 gptkb:HSP90AB1 gptkb:TRAP1
gptkbp:bfsLayer	8