|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:HSP27
HSP25
HSP28
|
|
gptkbp:category
|
small heat shock protein
stress protein
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:HSPB1_gene
|
|
gptkbp:Entrez_Gene_ID
|
3315
ENSG00000106211
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Heat_shock_protein_beta-1
|
|
gptkbp:function
|
molecular chaperone
prevents aggregation of denatured proteins
inhibits apoptosis
involved in actin cytoskeleton organization
involved in stress resistance
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSPB1
|
|
gptkbp:interactsWith
|
gptkb:actin
gptkb:BAG3
gptkb:HSP70
gptkb:HSP90
tubulin
alphaB-crystallin
|
|
gptkbp:length
|
205 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
7q11.23
|
|
gptkbp:molecularWeight
|
27 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Charcot-Marie-Tooth_disease_type_2F
gptkb:distal_hereditary_motor_neuropathy_type_II
|
|
gptkbp:OMIM
|
602195
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Hspb1
|
|
gptkbp:orthologInZebrafish
|
hspb1
|
|
gptkbp:overexpressedIn
|
gptkb:skeletal_muscle
brain
heart
|
|
gptkbp:PDB
|
4MJH
|
|
gptkbp:phosphorylates
|
gptkb:MAPKAPK2
gptkb:MAPKAPK3
Ser15
Ser78
Ser82
|
|
gptkbp:RefSeq
|
NM_001540
|
|
gptkbp:regulates
|
upregulated by cytokines
upregulated by oxidative stress
upregulated by heat shock
upregulated by heavy metals
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P04792
|
|
gptkbp:bfsParent
|
gptkb:HSP27
gptkb:CMT2
|
|
gptkbp:bfsLayer
|
7
|