|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
cardiac hypertrophy
Brachydactyly mental retardation syndrome
|
|
gptkbp:component
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
gptkb:Grozinger_et_al.
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:encodes
|
HDAC4 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000068024
9759
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:testis
brain
heart
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_4
|
|
gptkbp:function
|
neuronal survival
regulation of transcription
muscle development
histone deacetylase activity
histone deacetylation
|
|
gptkbp:GOProcess
|
chromatin modification
regulation of gene expression
|
|
gptkbp:HGNC_ID
|
gptkb:HDAC4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HDAC4 gene
|
|
gptkbp:inhibitedBy
|
gptkb:valproic_acid
gptkb:trichostatin_A
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:SMAD3
gptkb:HDAC3
RUNX2
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
2q37.3
|
|
gptkbp:mutationAssociatedWith
|
intellectual disability
skeletal abnormalities
|
|
gptkbp:OMIM
|
605314
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Hdac4
|
|
gptkbp:proteinFamily
|
histone deacetylase family
class IIa HDAC
|
|
gptkbp:regulates
|
gptkb:MEF2_transcription_factors
phosphorylation
calcium signaling
nuclear export
|
|
gptkbp:UniProtID
|
gptkb:P56524
|
|
gptkbp:bfsParent
|
gptkb:HDAC4
|
|
gptkbp:bfsLayer
|
8
|