|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
neuronal survival
skeletal development
muscle differentiation
cardiac hypertrophy
|
|
gptkbp:EC_number
|
3.5.1.98
|
|
gptkbp:encodedBy
|
gptkb:HDAC4_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulates gene expression
removes acetyl groups from lysine residues on histone proteins
involved in transcriptional repression
involved in chromatin remodeling
|
|
gptkbp:gene
|
gptkb:HDAC4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Histone deacetylase 4
|
|
gptkbp:inhibitedBy
|
gptkb:valproic_acid
gptkb:trichostatin_A
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:MEF2_transcription_factors
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
2q37.3
|
|
gptkbp:member
|
histone deacetylase family
|
|
gptkbp:molecularWeight
|
120 kDa
|
|
gptkbp:orthologInMouse
|
Hdac4
|
|
gptkbp:regulates
|
phosphorylation
|
|
gptkbp:UniProtID
|
gptkb:P56524
|
|
gptkbp:bfsParent
|
gptkb:HDAC4
|
|
gptkbp:bfsLayer
|
8
|