|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:GON-10
gptkb:HD1
gptkb:RPD3
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
cardiovascular diseases
|
|
gptkbp:biologicalProcess
|
DNA repair
cell cycle regulation
regulation of gene expression
histone deacetylase activity
|
|
gptkbp:encodedBy
|
gptkb:HDAC1_gene
|
|
gptkbp:Entrez_Gene_ID
|
3065
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.5.1.98
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_1
|
|
gptkbp:function
|
histone deacetylation
transcriptional repression
chromatin remodeling
|
|
gptkbp:gene
|
gptkb:HDAC1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HDAC1 (human)
|
|
gptkbp:inhibitedBy
|
gptkb:Valproic_acid
gptkb:Vorinostat
Trichostatin A
|
|
gptkbp:interactsWith
|
gptkb:HDAC2
gptkb:RB1
gptkb:SIN3A
gptkb:TP53
MTA2
|
|
gptkbp:length
|
482 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p35.2
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
HDAC1 (mouse)
Rpd3 (yeast)
|
|
gptkbp:partOf
|
gptkb:NuRD_complex
CoREST complex
Sin3A complex
|
|
gptkbp:PDB
|
4BKX
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
acetylation
|
|
gptkbp:RefSeq
|
gptkb:NP_004955.2
|
|
gptkbp:regulates
|
transcriptional
post-translational
|
|
gptkbp:structure
|
contains deacetylase domain
|
|
gptkbp:UniProtID
|
Q13547
|
|
gptkbp:bfsParent
|
gptkb:RPD3
|
|
gptkbp:bfsLayer
|
8
|