G protein-coupled receptor kinase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:GRK
gptkbp:associatedWith	gptkb:Parkinson's_disease heart failure hypertension
gptkbp:contains	serine/threonine kinase domain
gptkbp:discoveredBy	gptkb:Robert_J._Lefkowitz
gptkbp:enzymeClassification	EC 2.7.11.16
gptkbp:firstDescribed	late 1980s
gptkbp:foundIn	eukaryotes
gptkbp:function	phosphorylation of G protein-coupled receptors
gptkbp:GO_term	GO:0004706
https://www.w3.org/2000/01/rdf-schema#label	G protein-coupled receptor kinase
gptkbp:includes	gptkb:GRK1 gptkb:GRK2 gptkb:GRK3 gptkb:GRK4 gptkb:GRK5 gptkb:GRK6 gptkb:GRK7
gptkbp:involves	desensitization of GPCRs
gptkbp:locale	gptkb:cytoplasm gptkb:plasma_membrane
gptkbp:member	gptkb:protein_kinase_superfamily
gptkbp:orthologIn	gptkb:human gptkb:mouse gptkb:zebrafish gptkb:Caenorhabditis_elegans gptkb:Drosophila_melanogaster right
gptkbp:pathway	visual phototransduction beta-adrenergic receptor signaling dopamine receptor signaling olfactory signaling pathway
gptkbp:PDB	yes
gptkbp:regulates	gptkb:G_protein-coupled_receptor_signaling regulated by phosphorylation activated by G protein beta-gamma subunits regulated by protein-protein interactions
gptkbp:relatedTo	receptor internalization arrestin recruitment
gptkbp:structure	C-terminal domain central kinase domain N-terminal regulator of G protein signaling homology domain
gptkbp:substrate	gptkb:G_protein-coupled_receptor
gptkbp:UniProtID	gptkb:Signal_transduction gptkb:Transferase Kinase
gptkbp:bfsParent	gptkb:GRK
gptkbp:bfsLayer	7