|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
GPRK5
beta-adrenergic receptor kinase 3
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cardiovascular_disease
heart failure
hypertension
|
|
gptkbp:biologicalProcess
|
signal transduction
protein serine/threonine kinase activity
receptor internalization
|
|
gptkbp:clinicalVariant
|
Q41L polymorphism
|
|
gptkbp:discoveredBy
|
Benovic et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodes
|
GRK5 protein
|
|
gptkbp:Entrez_Gene_ID
|
2869
ENSG00000198873
|
|
gptkbp:expressedIn
|
gptkb:cancer
brain
heart
|
|
gptkbp:fullName
|
G protein-coupled receptor kinase 5
|
|
gptkbp:function
|
regulates receptor desensitization
phosphorylates activated G protein-coupled receptors
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:4556
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GRK5
|
|
gptkbp:inhibitedBy
|
gptkb:heparin
|
|
gptkbp:length
|
590
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
10q26.11
|
|
gptkbp:molecularWeight
|
67 kDa
|
|
gptkbp:OMIM
|
600465
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Grk5
|
|
gptkbp:PDB
|
4TNB
|
|
gptkbp:phosphorylates
|
gptkb:beta-adrenergic_receptor
gptkb:muscarinic_acetylcholine_receptor
|
|
gptkbp:postTranslationalModification
|
phosphorylation
myristoylation
|
|
gptkbp:proteinFamily
|
G protein-coupled receptor kinase family
|
|
gptkbp:regulates
|
GPCR signaling
beta-adrenergic receptor desensitization
muscarinic receptor desensitization
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
P34947
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptor_kinase
|
|
gptkbp:bfsLayer
|
8
|