|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
ADRBK2
beta-adrenergic receptor kinase 2
|
|
gptkbp:discoveredBy
|
gptkb:Robert_J._Lefkowitz
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
ADRBK2 gene
|
|
gptkbp:Entrez_Gene_ID
|
156
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.16
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
brain
heart
liver
|
|
gptkbp:fullName
|
G protein-coupled receptor kinase 3
|
|
gptkbp:function
|
phosphorylates activated G protein-coupled receptors
|
|
gptkbp:HGNC_ID
|
HGNC:288
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GRK3
|
|
gptkbp:interactsWith
|
gptkb:G_protein_beta-gamma_subunits
gptkb:clathrin
arrestin
|
|
gptkbp:involvedIn
|
receptor desensitization
internalization of GPCRs
regulation of receptor signaling
|
|
gptkbp:locatedOnChromosome
|
gptkb:22q11.21
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
80 kDa
|
|
gptkbp:mutationAssociatedWith
|
bipolar disorder
schizophrenia
|
|
gptkbp:OMIM
|
601692
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2ACX
4JQI
|
|
gptkbp:phosphorylates
|
gptkb:beta-adrenergic_receptor
gptkb:alpha-adrenergic_receptor
opioid
|
|
gptkbp:postTranslationalModification
|
phosphorylation
myristoylation
|
|
gptkbp:RefSeq
|
NM_005159
|
|
gptkbp:relatedTo
|
signal transduction
desensitization of GPCRs
|
|
gptkbp:UniProtID
|
P35626
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptor_kinase
|
|
gptkbp:bfsLayer
|
8
|