|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
BARK1
beta-adrenergic receptor kinase 1
|
|
gptkbp:associatedWith
|
heart failure
myocardial infarction
hypertension
|
|
gptkbp:discoveredBy
|
gptkb:Robert_J._Lefkowitz
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
ADRBK1 gene
|
|
gptkbp:Entrez_Gene_ID
|
156
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.16
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
heart
liver
|
|
gptkbp:fullName
|
G protein-coupled receptor kinase 2
|
|
gptkbp:function
|
regulates receptor desensitization
phosphorylates activated G protein-coupled receptors
|
|
gptkbp:HGNC_ID
|
HGNC:288
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GRK2
|
|
gptkbp:inhibitedBy
|
gptkb:paroxetine
CMPD101
|
|
gptkbp:interactsWith
|
gptkb:G_protein_beta-gamma_subunits
beta-arrestin
|
|
gptkbp:locatedOnChromosome
|
11q13.4
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~80 kDa
|
|
gptkbp:OMIM
|
600866
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2BCJ
3KRW
|
|
gptkbp:phosphorylates
|
gptkb:beta-adrenergic_receptor
gptkb:rhodopsin
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:RefSeq
|
NM_002741
|
|
gptkbp:regulates
|
activated by G protein beta-gamma subunits
inhibited by calmodulin
|
|
gptkbp:structure
|
contains a protein kinase domain
contains a regulator of G protein signaling homology (RH) domain
|
|
gptkbp:UniProtID
|
P25098
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptor_kinase
gptkb:RKIP
|
|
gptkbp:bfsLayer
|
8
|