|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeSplicing
|
gptkb:GABBR1_isoforms
gptkb:GABBR2_isoforms
|
|
gptkbp:associatedWith
|
gptkb:depression
addiction
epilepsy
spasticity
anxiety disorders
|
|
gptkbp:binds
|
gptkb:gamma-aminobutyric_acid
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:effect
|
reduces neuronal excitability
|
|
gptkbp:encodedBy
|
gptkb:GABBR1
gptkb:GABBR2
|
|
gptkbp:enemyOf
|
gptkb:CGP_35348
gptkb:baclofen
gptkb:phaclofen
gptkb:saclofen
|
|
gptkbp:expressedIn
|
neurons
astrocytes
|
|
gptkbp:foundIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:function
|
inhibitory neurotransmission
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GABA B receptor
|
|
gptkbp:involvedIn
|
memory
pain modulation
synaptic transmission
muscle relaxation
anxiety regulation
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6p21.3_(GABBR1)
gptkb:chromosome_9q22_(GABBR2)
|
|
gptkbp:modulatedBy
|
gptkb:potassium_channels
neurotransmitter release
adenylyl cyclase activity
cAMP levels
calcium channels
|
|
gptkbp:OMIM
|
603540
|
|
gptkbp:relatedTo
|
gptkb:GABA_A_receptor
gptkb:GABA_C_receptor
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:subunit
|
gptkb:GABBR1
gptkb:GABBR2
|
|
gptkbp:targetOfDrug
|
anticonvulsant drugs
antispastic drugs
anxiolytic drugs
|
|
gptkbp:type
|
G protein-coupled pathway
|
|
gptkbp:UniProtID
|
gptkb:O75899_(GABBR2)
Q9UBS5 (GABBR1)
|
|
gptkbp:bfsParent
|
gptkb:GABA
gptkb:G_protein-coupled_receptor
|
|
gptkbp:bfsLayer
|
5
|